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 Cancer in pregnancy
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 ECV Uterine relaxation
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 > STAN followup
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 Wat bevalt beter


STAN follow-up study


A 2-years and 5-years follow-up on neurological and behavioural outcome of the Dutch STAN®-trial



Fetal surveillance aims to protect the fetus from severe metabolic acidosis. Intrapartum monitoring using a combination of ST-analysis of the fetal ECG and cardiotocography seems to have a favourable effect on the incidence of metabolic acidosis of the newborn fetus. It is unknown however, if these effects also result in better long-term neurological and/or behavioural outcome.



To investigate the effect of intrapartum ST-analysis of the fetal ECG on long-term neurological and behavioural development compared to intrapartum monitoring with conventional cardiotocography (CTG).


Design, setting, and participants

Follow-up study of the Dutch STAN® trial: a randomised controlled trial in which 5681 women in labour with a singleton pregnancy in cephalic position were randomly assigned to fetal surveillance with ST-analysis of the fetal ECG in combination with cardiotocography (index) or cardiotocography alone (control).



Parents of selected children will be asked to complete three questionnaires at the appropriate age of their child: a general questionnaire concerning educational level of the parents and possible medical interventions of the child thusfar; an age-appropriate Ages and Stages questionnaire (ASQ-3) which gives information about the neurological development of the child and an age-appropriate Child Behavioural Checklist which gives information about the neurological development of the child.

Three groups of children will be selected: all children born with an adverse outcome and a random selection of the same number of children born with an umbilical cord pH between 7.05 and 7.15 and a random selection of children born with an umbilical cord pH above 7.15.


Knowledge transfer

The results will be submitted to national and international peer reviewed journals



The 5-years follow-up study will begin in January 2011 and end in July 2013

The 2-years follow-up study began in January 2008 and ended in July 2010


Project group

Drs. J.H. Becker

Dr. A. Kwee

Prof. Dr. B.W. Mol

Prof. Dr. G.H.A. Visser



Drs. J.H. Becker: j.h.becker@umcutrecht.nl