FetaL Abdominal Markers Identified by ultrasound to predict Neonatal Gastroschisis Outcome
Go to the flamingo website
Various attempts have been made to correlate findings on antenatal ultrasound examination with neonatal outcome. Reports are conflicting because of the small size of study populations, retrospective study designs, the short time of follow up and the non standardized method and timing of ultrasound examination.
In contrast to previous studies we propose a prospective longitudinal multi centre study with fetal ultrasound assessment and surveillance according to a standard protocol.
Our overall objective is to identify antenatal ultrasound markers that predict the time to full enteral feeding in children with gastroschisis. These antenatal ultrasound markers may influence the antenatal obstetric management in order to improve the neonatal outcome.
The mode and timing of delivery will be according to the local hospital policy.
The second part of the study is the follow up of the newborns with gastroschisis.
Data will be collected during: labour, birth, surgery, admission on neonatal intensive care unit, admission on paediatric surgery department and out-patient visits.
Patients are asked to complete a questionnaire concerning the development of their child at when it is 24 months of age.
· Time to introduction of full enteral feeding after birth expressed in days. Corresponding with the discontinuation of parenteral nutrition.
· Secondary outcome:
· Intra uterine death
· Visual bowel condition at birth
· Number of days to complete defect closure
· Complications (gastro intestinal tract or others)
· Neurologic development
The prevalence of gastroschisis is 1-3 per 10.000 living births. The total number of living births in the Netherlands is approximately 180.000. This means there are at least 18 cases of gastroschisis in the Netherlands a year. During a study period of 4 years, this amount can be expected to be over 70 cases.
We assume that the majority of patients with gastroschisis will participate in the study, since there is no associated risk and the only burden of the study is to complete two short questionnaires.
drs. C.C.M.M. Lap, PhD student
dr. G.T.R. Manten, Gynaecologist, UMC Utrecht
dr. L.R. Pistorius, Gynaecologist UMC Utrecht
prof. dr. G.H.A. Visser, Gynaecologist, UMC Utrecht
drs. C.C.M.M. Lap