Oil-bases contrast versus water-based contrast media in the diagnosis of tubal patency at hysterosalphingography
Go to the H2Olie website.
In the evaluation of female subfertility, hysterosalpingography (HSG) is an important examination because of its diagnostic value. The procedure delineates the uterine cavity contours and the rugation and the patency of the fallopian tubes. Since the introduction of HSG as a diagnostic test, various contrast media have been used, from water-soluble to oil-soluble, ionic to nonionic, and high osmolarity to low osmolarity.
A possible therapeutic effect of diagnostic tubal patency testing has been debated in the literature for more than 50 years.
There are some small studies that show that flushing with Oil-soluble contrast medium (OSCM) has a significant higher odds ratio of live birth compared to flushing with Water-soluble contrast medium (WSCM). But other small studies showed no significant different in odds ratio of pregnancy or live births after flushing during HSG examination with OSCM or WSCM.
A multicenter study
Secondary outcomes: live birth rates, miscarriages, ectopic pregnancies, pain score.
Nature and extend of the burden and risk associated with participation, benefit and group relatedness
As we compare strategies that are already applied in current practice, no additional risks or burdens are expected from the study.
drs. K. Dreyer, MD/researcher, VU Medical Center
dr. P.G.A. Hompes, gynecologist, VU Medical Center
Prof. dr. B.W. Mol, gynecologist, Academic Medical Center
Drs. K. Dreyer, MD/researcher
VU Medical Center
Tel: 020-4445277 / 06-42312075