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HyRAS

 

Hypitat Risk Assessment Study: A 2-year follow-up to the Hypitat study.

 

Go to the HyRAS website.

 

Background

Secondary prevention of cardiovascular disease (CVD) is difficult, partly due to the lack of an effective strategy to identify individuals at high risk, at an age young enough to benefit from preventive interventions. This study follows a high risk strategy, using the novel concept of pregnancy as a cardiovascular challenge test. Ten to fifteen percent of pregnant women experience gestational

hypertension (GH) or preeclampsia (PE) at term. These women have been demonstrated to be at increased risk to develop CVD later in life.

 

Aims

(i) To screen women who have experienced GH or PE at term for risk factors for CVD, two years after their complicated pregnancy. (ii) To estimate the 10-year cardiovascular event risk in these women using validated prediction algorithms, in order to establish the proportion that is likely to benefit from preventive interventions, according to widely accepted guidelines.

 

Design, setting, and participants

Case control study in the 35 Dutch hospitals participating in the nationwide HYPITAT-study. Participants will be 1200 women of Dutch and foreign origin.

 

Procedures

Age, ethnicity, smoking status, antihypertensive medication, parental history of (premature) cardiovascular events, systolic blood pressure, body height, body weight, and waist and hip circumference, and fasting levels of total plasma cholesterol, HDL cholesterol, triglycerides, hs CRP, insulin, glucose, and HbA1c and microalbuminuria will be determined two years after pregnancy. Individual 10-year cardiovascular event risks will be estimated using the Adult Treatment Panel III risk score, Reynolds Risk Score and QRISK.

 

Knowledge transfer

Design of a future intervention study, to evaluate the feasibility and effectiveness of preventive strategies in women who experience term GH or PE and have a 10-year cardiovascular event risk >10%. Furthermore the result will be submitted to national and international peer reviewed journals.

 

Duration

Duration of the study is 24 months

 

Project group
Dr. C.J.M. de Groot

Dr. A. Franx

Dr. K.W.M. Bloemenkamp

Dr. M. van Pampus

Dr. B.W. Mol

 

Subsidy

Nuts/Ohra Stichting