HTA Preference study
Health Technology Assessment (HTA)
Many clinical studies in obstetrics face a multidimensional outcome, resulting in complex decisions on the design, analysis and derivation of recommendations. A prototypical outcome problem is at the core of this HTA-study.
When problems arise during third trimester pregnancy (e.g. pre-eclampsia, suspected growth retardation) the obstetrician has to choose between a watchful waiting versus an active (induction of labour) strategy. Active policy: less risk of intrauterine death, more risk on prematurity, labour complications, disadvantages of a CS; watchful waiting involves the reverse. Probabilities of these events range from rare to universal, and the weights attached to these outcomes show a broad range.
We propose to compare head-to-head methodologies in use in socalled preference and utility measurement to arrive at a prefered method to measure and analyse these multidimensional outcomes. The primary comparison will be the 'attitude' method based in psychology, applying, for short rating scales and sophisticated analysis to cover personal effects and error, and the 'preference' method based in economics, with 2 branches: indirect trade-offs with an artificial calibration scale as in time trade-off or WTP, or socalled direct discrete choice experimentation (DCE) choosing between 2 vignettes, as in conjoint analysis).
Prof. Dr. G.J. Bonsel, AMC Amsterdam
Dr. E. Birnie, AMC Amsterdam
Dr. B.W. Mol MMC Veldhoven
Drs. D. Bijlenga, AMC Amsterdam
ZonMw - www.zonmw.nl
April 2005 to march 2008
HTA protocol (Pdf)
HTA in de Obstetrie (Pdf) - artikel uit Nederlands Tijdschrift voor Obstetrie en Gynaecologie, vol.119, oktober 2006.
When outcome is a balance - BMC Pregnancy and Childbirth 2007, 7:10