Follow Up

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INeS Follow-up
Medically assisted reproduction techniques: do they influence the offspring’s growth, health and neurodevelopment? Follow-up of a randomized controlled trial.

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The INeS Follow-up study will study the effect of type of medically assisted reproduction on offspring’s health. More specifically, does treatment of subfertile couples by in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with controlled ovarian hyperstimulation (IUI-COH) affect their child’s general health, growth, body composition, cardiometabolic health, development and behavior at age 4-6 years.

Study design
The INeS Follow-up study will investigate children conceived during the INeS-study
(registered as NL12782.018.07). The INeS-study was a multi-center, randomized
controlled non-inferiority trial consisting of three arms. Couples seeking fertility treatment after at least
12 months of unprotected intercourse were randomly allocated to IVF-SET (n= 201), IVF-MNC
(n=194) or IUI-COH (n=207). The INeS Follow-up study will gather data by means of
questionnaires and by measurements in a mobile research vehicle close to the participants home. All
data of the INeS Follow-up study will be coupled to data of the INeS study.

Study population
Offspring of parents who participated in the INeS-study. The children had to be conceived within 12 months after their parents were randomized to IVF-SET, IVF-MNC or IUI-COH. Children were born between 2009 and 2013. A total of 354 children will be invited to participate in this follow-up study at age 4-6 years.

In the INeS study, women were randomly allocated to IVF-SET, IVF-MNC or IUI-COH. There will be no intervention in the follow-up study.

Outcome measures
Between birth and age 4-6 years:
General health
Growth trajectory

At age 4-6 years:
Body composition
Cardiovascular health
Metabolic health

Prof. dr. T.J Roseboom, Department of Obstetrics and Gynaecology/Department of Clinical Epidemiology, Biostatistics and Bioinformatics, AMC Amsterdam

Drs. S. Mintjens, aio, VUmc,, 020-4445238
Drs. M.D. Menting, oio AMC,, 020-5661472
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