Obstetrics

 
 APOSTEL VIII
 
 Dutch TRUFFLE
 
 2Close
 
 APRIL
 Highlow
 
 PC
 Quadruple P
 
 SIMPLE III
 
 Stop or Go?
 
 STRIDER
 
 SUGAR-DIP
 
 KEUZEHULP IMPLEMENTATIE
 
 INDEX
 MOTHER
 NethOSS
 Ppromexil-III
 ALLO
 AMPHIA
 APOSTEL-I
 APOSTEL-II
 APOSTEL-III
 APOSTEL-IV
 
 Apostel VI
 ASB
 CHIPS
 DIGITAT
 ECV Implementation
 EuFis
 Fluxim
 GlucoMOMS
 HTA Longterm conseq.
 HTA Preference study
 HYPITAT
 HYPITAT-II
 HyRAS (Hypitat followup)
 Implementatie Tour
 IUPC
 PIMPP
 PPROMCerclage
 PPROMEXIL
 PreCare
 PROBAAT
 PROBAAT-II
 > PROBAAT-S
 ProTWIN
 SimpleII
 STAN
 TeMpOH-1
 TeMpOH-3
 TOSTI
 TOTEM
 Triple P
 TRUFFLE
 WOMB study

 ABCD-study
 BIG CHANGE
 CAMPUR
 Cancer in pregnancy
 Doula study
 ECV tocolysis
 ECV Uterine relaxation
 EuroHeartSurvey
 FRUIT
 HP4ALL-PC
 HP4ALL-RS
 IMPACT
 INCAS
 IRIS
 Keizerlijk litteken
 MAKE
 OOPUS
 PRELHUDE
 PROMISES
 RAVEL
 SIMPLE
 STAN followup
 VET study
 VIS-project
 Wat bevalt beter
 ZAHARA II
 ZAHARA 3
 ZOBASII
 

 

PROBAAT-S

Prostaglandin or Balloon catheter for induction of labour after previous caesarean section

Go to the PROBAAT-S website

Background
Women with a previous caesarean section entering a trial of labour have an increased risk of repeat caesarean section, especially when labour is induced. In the Netherlands, labour in women with a previous caesarean section is mostly induced with a transcervical Foley catheter or with intravaginal prostaglandin gel when the cervix is unfavourable. When the cervix is favourable, labour may be induced by amniotomy. Some hospitals do not induce labour at all in women with a previous caesarean section and thus perform an elective repeat caesarean section. The best method of induction of labour in this group of women is still controversial. Induction by Foley catheter and especially prostaglandins are associated with increased uterine scar rupture rate. To date, studies have focused on uterine scar rupture rate or caesarean rate when comparing prostaglandins to Foley catheter for induction of labour. Studies concerning induction of labour by Foley catheter show its efficacy and safety although they include cohorts not larger than n=161.

Objective
To study the methods of induction of labour in women with a previous caesarean section and their respective effectiveness and safety, i.e. neonatal and maternal morbidity in the Netherlands.

Study design
A national prospective observational cohort study.

Study population
Pregnant women with a history of one previous caesarean section and an indication for induction of labour in the current pregnancy.

Methods
All women with one previous caesarean section and an indication for induction of labour will be treated according to their local hospital protocol who may induce by prostaglandins, Foley catheter, amniotomy or oxytocine. Hospitals that do not induce labour in this group of women perform a repeat caesarean section. All women will be registered and information concerning their (obstetrical) history, pregnancy, mode of delivery and puerperium will be collected as well as neonatal data until discharge. All data will be collected anonymously in a web-based file.

Outcome measures
Primary outcome will be neonatal and maternal morbidity. Secondary outcome measures will be mode of delivery, including subanalysis of Foley catheter versus prostaglandins, induction-to-delivery interval and costs.

Inclusions
We aim to include 1500 women in a two-year period starting on August 1st 2011.    
              
Time schedule
36 months. 6 months preparation, 24 months inclusions, 6 months data analysis.

Projectleader
Dr. Bloemenkamp, gynaecologist, Leiden University Medical Centre, Leiden


 

Projectgroup
Drs. M. Józwiak, Groene Hart Ziekenhuis, Gouda
Dr J.W. de Leeuw, Ikazia Ziekenhuis Rotterdam
Dr. B.W. Mol, Academic Medical Centre, Amsterdam
Dr. M.G.van Pampus, OLVG Amsterdam
Dr. A. Kwee, UMCU, Utrecht
Prof. dr J. van Roosmalen, LUMC, Leiden

Subsidy
1.
Grant from ”Werkgroep Perinatologie en Maternale Ziekten (working party of
    Dutch Society of Obstetrics and Gynaecology).
2.
Grant from Dutch Consortium in Obstetrics, Fertility and Gynaecology.

Contact
Drs. Claartje Huisman, 
Main researcher
Leiden University Medical Centre

Contact information:
Email:
probaat-s@studies-obsgyn.nl
Postal address:
Afdeling Verloskunde K-06-P/35
Postbus 9600
2300 RC Leiden
Telephonenumber: +31-6-46 08 82 35
Faxnumber: 071-526 6741