Welcome to the ALIFE2 Study homepage

In total there will be 399 inclusions, approximately 100 will be performed by the NL-team (including all international non-UK sites) and 300 will be done by the UK-team.

Total registrations: 401/401

Total randomizations: 279/401

Total registrations NL-team : 128/128

Total randomizations NL-team: 115/128

Total registrations UK-team: 273/300

Total randomizations UK-team: 164/300  

Last update: 18 February 2020


Anticoagulants for living fetuses in women with recurrent miscarriage and inherited thrombophilia

NTR 3361

METC 2012_173

ABR NL40256.018.12

Are you an (international) physician willing to participate in the ALIFE2 study? Please contact Eva HamulyŠk at e.n.hamulyak@amc.nl.



February 2020

With more than 50 international centers contributing to the ALIFE2 study, we have reached the huge milestone of 400 registered women! A huge thank you to all the participating women and investigators, we are getting so close to having answer to this important research question!

September 2019

Wonderful news: as of September 18, we have 250 randomizations in the ALIFE2 study!!

November 2018

Medizinische Universitšt Innsbruck, Austria is now a participating center! We are approaching 300 registrations and 200 randomizations in the ALIFE2 trial!

May 2017

CHU Sainte-Justine in Montreal, Canada has opened for recruitment!

December 2016

First ALIFE2 randomization in University Medical Center Ljubljana!

October 2016

Great news! First ALIFE2 randomization in the USA! The University of Illinois at Chicago has included the first participant!

May 2016

The University Medical Center Ljubljana in Slovenia has opened for recruitment!

January 2016

The University of Illinois at Chicago has opened for recruitment!

October 2015

Warwick Medical School, the first UK-ALIFE2 team (NHS grant) site has opened for inclusion!!

May 2015

The ALIFE2 protocol has been published in TRIALS! (link here)